Formate—dihydrofolate ligase

formate—dihydrofolate ligase
Identifiers
EC number 6.3.4.17
CAS number 123303-25-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a formate—dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction

ATP + formate + dihydrofolate \rightleftharpoons ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming). Other names in common use include formyltransferase, dihydrofolate, dihydrofolate formyltransferase, and formyl dihydrofolate synthase.

References

Further reading

  • Drake JC, Baram J, Allegra CJ (1990). "Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells". Biochem. Pharmacol. 39 (3): 615–8. doi:10.1016/0006-2952(90)90073-T. PMID 2306274.